A mysterious artifact called the Tablet of Order and Chaos gets shattered into four pieces, creating problems with reality. A mystic within the Amazing Universe, who is confirmed to not be a current or former Sorcerer Supreme,[1] will tell Spider-Man how he can fix this, by going into three different dimensions (aside from his own), get help from the different Spider-Men in each dimension, and recover the tablet fragment in each.

Each dimensions’ Spider-Man has a unique fighting technique that distinguishes him from the others. Amazing Spider-Man of Earth-616 implements various web-attacks, such as web hammers and maces. Spider-Man Noir of Earth-7207 uses stealth tactics and timing to silently defeat his enemies. Spider-Man 2099 of Earth-928 is air driven, using high-flying acrobatics and his suits’ special abilities. Ultimate Spider-Man of Earth-1610 uses the powers of the symbiote suit to devastate hordes of enemies, generating symbiotic spikes and tendrils. Drawing on these qualities is a stylized “Spider Sense” for each Spiderman. Noir is based on stealth when your safely concealed in the shadows and thus invisible to your enemies the screen turns black and white, when your exposed in light the screen is colored in meaning someone can see you. Spiderman 2099 has the abillity to slow down time around him while he moves at normal speed allowing him to quickly dodge attacks such as lasers, Bombs or missiles.